Reliance & Single IRB (sIRB) Resources
Getting Started
Workflow Diagrams
Presentations
Presentation - What You Need to Know About Single IRB Review: Principles and Practice (Part 1) - July 2020
Presentation - What You Need to Know About Single IRB Review: Principles and Practice (Part 2) - August 2020
Presentation - ORSC Protocol Navigator Procedures Workgroup 2022: Overview: NIH Multi-Site Protocol Processes - July 2022
Presentation - The Single IRB Model at the NIH: Principles, Processes, and Pitfalls - November 2023
NIH HRPP Policy Framework
Agreement Requests
Request a Reliance Agreement
Use the link below to request a Reliance Agreement when an NIH Study Team wants to rely on an external IRB or an NIH Study Team wants external Participating Sites to rely on the NIH IRB.
Request a Federalwide (FWA) Coverage Agreement
Complete this form if you are an NIH PI/designee and you want the NIH to extend its FWA to an investigator who will either be leaving, or has left, the NIH.
NIH is Lead Study Team using NIH IRB as the Reviewing IRB (sIRB)
For consent templates please navigate to the IRB Templates page.
NIH as Participating Site Study Team & Relying on an External IRB (sIRB)
Relying on WCG IRB (formerly WIRB)
Guidance - Using NIH funds to Pay for Advarra or WCG IRB Services.pdf
Video - WIRB Orientation for Investigators and Research Team
Relying on Advarra
Guidance - Using NIH funds to Pay for Advarra or WCG IRB Services.pdf
Video - Advarra Orientation for Investigators and Research Team
sIRB Mandates
The NIH sIRB Policy
Final NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research
NIH Single IRB Policy in the Context of the Intramural Research Program
NIH Single IRB Policy in the Context of the Intramural Research Program: Seeking an Exception
New Process for Requesting Exceptions to the NIH Single IRB Requirements
Revised Common Rule: Cooperative Research
The Revised Common Rule's Cooperative Research Provision (45 CFR 46.114)
Helpful Links
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