Reliance & Single IRB (sIRB) Resources
Getting Started
Workflow Diagrams
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Presentations
Presentation - What You Need to Know About Single IRB Review: Principles and Practice (Part 1) - July 2020
Presentation - What You Need to Know About Single IRB Review: Principles and Practice (Part 2) - August 2020
Presentation - ORSC Protocol Navigator Procedures Workgroup 2022: Overview: NIH Multi-Site Protocol Processes - July 2022
Presentation - The Single IRB Model at the NIH: Principles, Processes, and Pitfalls - November 2023
NIH HRPP Policy Framework
Agreement Requests
Request a Reliance Agreement
Use the link below to request a Reliance Agreement when an NIH Study Team wants to rely on an external IRB or an NIH Study Team wants external Participating Sites to rely on the NIH IRB.
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Request a Federalwide (FWA) Coverage Agreement
Complete this form if you are an NIH PI/designee and you want the NIH to extend its FWA to an investigator who will either be leaving, or has left, the NIH.
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NIH is Lead Study Team using NIH IRB as the Reviewing IRB (sIRB)
For consent templates please navigate to the IRB Templates page.
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Presentation- NIH Investigators and Multi-Site Research-February, 2024
NIH as Participating Site Study Team & Relying on an External IRB (sIRB)
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Relying on WCG IRB (formerly WIRB)
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Guidance - Using NIH funds to Pay for Advarra or WCG IRB Services.pdf
Video - WIRB Orientation for Investigators and Research Team
Relying on Advarra
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Guidance - Using NIH funds to Pay for Advarra or WCG IRB Services.pdf
Video - Advarra Orientation for Investigators and Research Team
sIRB Mandates
The NIH sIRB Policy
Final NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research
NIH Single IRB Policy in the Context of the Intramural Research Program
NIH Single IRB Policy in the Context of the Intramural Research Program: Seeking an Exception
New Process for Requesting Exceptions to the NIH Single IRB Requirements
Revised Common Rule: Cooperative Research
The Revised Common Rule's Cooperative Research Provision (45 CFR 46.114)
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